preparation of [111in]-bleomycin radiopharmaceutical [persian]

نویسندگان

amir reza jalilian

mohammad mirzaie

alireza karimian

jamshid moafian

gholamreza aslani

چکیده

in this study, the preparation of 111in-bleomycin complex was optimized for temperature, time, concentration and ph during several experiments. the results showed that by the addition of bleomycin to 111in-incl3 sample (dried under flow of n2) and heating the mixture up to 90-100°c the radiopharmaceutical can be obtained in 99.5% yield and a specific activity of 1.745 ci/mmol. the final sample was injected into fibrosarcoma-bearing mice via their tail vein. satisfactory preliminary spect images were acquired between 2-4 hours post-injection showing suitable accumulation in fibrosarcoma tumors.

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Preparation of [111In]-Bleomycin radiopharmaceutical [Persian]

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عنوان ژورنال:
iranian journal of nuclear medicine

ناشر: tehran university of medical sciences

ISSN 1681-2824

دوره 13

شماره 1 2004

کلمات کلیدی
[ ' r a d i o p h a r m a c e u t i c a l ' , ' i n ' , 1 1 1 , ' b l e o m y c i n ' , ' f i b r o s a r c o m a ' ]

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