preparation of [111in]-bleomycin radiopharmaceutical [persian]
نویسندگان
چکیده
in this study, the preparation of 111in-bleomycin complex was optimized for temperature, time, concentration and ph during several experiments. the results showed that by the addition of bleomycin to 111in-incl3 sample (dried under flow of n2) and heating the mixture up to 90-100°c the radiopharmaceutical can be obtained in 99.5% yield and a specific activity of 1.745 ci/mmol. the final sample was injected into fibrosarcoma-bearing mice via their tail vein. satisfactory preliminary spect images were acquired between 2-4 hours post-injection showing suitable accumulation in fibrosarcoma tumors.
منابع مشابه
Preparation of [111In]-Bleomycin radiopharmaceutical [Persian]
In this study, the preparation of 111In-Bleomycin complex was optimized for temperature, time, concentration and pH during several experiments. The results showed that by the addition of bleomycin to 111In-InCl3 sample (dried under flow of N2) and heating the mixture up to 90-100°C the radiopharmaceutical can be obtained in 99.5% yield and a specific activity of 1.745 Ci/mmol. The final s...
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Large quantities of radiopharmaceuticals prescribed for treatment and diagnosis are excreted through kidney. Therefore, radiation unwanted dose is created in kidney. As a result, exact calculation of prescribed radiopharmaceuticals amount is important. Monte Carlo method is used for simulation of radiation transport in body due to random nature of radiation. In this research, for the first time...
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عنوان ژورنال:
iranian journal of nuclear medicineناشر: tehran university of medical sciences
ISSN 1681-2824
دوره 13
شماره 1 2004
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